Thermo Fisher Scientific CD2 Monoclonal Antibody (S5.5), PE-Texas Red

Applications

• Flow Cytometry (Flow): Assay-dependent

Product Specifications

Additional Formats

• APC
• FITC
• PE
• PerCP
• Qdot 605
• Request custom conjugation

Product Specific Information

The R-phycoerythrin (PE)-Texas Red conjugate permits simultaneous multicolor labeling and detection of multiple targets with excitation by a single excitation source—the 488 nm line of the argon-ion laser.

Target Information

CD2 (LFA-2) is a monomeric surface antigen (MW range 45–58 kDa) of the human T-lymphocyte lineage expressed on all peripheral blood T cells. It is one of the earliest T-cell markers, present on more than 95% of thymocytes and also found on some natural killer cells, but not on B lymphocytes.
Monoclonal antibodies against CD2 inhibit rosette formation with sheep erythrocytes, indicating CD2’s role as the erythrocyte receptor or its close association.
CD2 interacts with CD58 to stabilize adhesion between T cells and antigen-presenting or target cells. Despite low affinity in solution, this interaction provides tight adhesion at the cell-cell interface.
T-cell activation increases CD2 expression and mobility, enhancing contact with CD58 and strengthening intercellular adhesion. CD2 deficiency reduces intestinal inflammation and aids infection control.
Diseases associated with CD2 dysfunction include penile squamous cell carcinoma and immune deficiency due to thymus absence.

Analyte Specific Reagent

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