Thermo Fisher Scientific CD2 Monoclonal Antibody (S5.5), PE-Cyanine5.5

Applications

• Flow Cytometry (Flow): Assay-dependent

Product Specifications

Additional Formats

• APC
• FITC
• PE
• PerCP
• Qdot 605
• Request custom conjugation

Product Specific Information

The R-phycoerythrin (PE)-Cy5.5 tandem conjugate permits simultaneous multicolor labeling and detection of multiple targets with excitation by a single excitation source—the 488 nm line of the argon-ion laser.

Target Information

CD2 (LFA-2) is a monomeric surface antigen (MW 45–58 kDa) of the human T-lymphocyte lineage, expressed on nearly all peripheral blood T cells and some natural killer cells, but not on B lymphocytes. CD2 is one of the earliest T-cell markers, present on over 95% of thymocytes.
Monoclonal antibodies against CD2 inhibit rosette formation with sheep erythrocytes, indicating its role as or association with the erythrocyte receptor. The CD2–CD58 interaction stabilizes adhesion between T cells and antigen-presenting or target cells. Although the affinity in solution is relatively low, cell-cell interactions enhance adhesion strength.
T cell activation increases CD2 expression and mobility, facilitating CD2–CD58 contact and strengthening intercellular adhesion. CD2 deficiency has been linked to reduced intestinal inflammation and infection control. Diseases associated with CD2 dysfunction include penile squamous cell carcinoma and immune deficiency due to thymic absence.

Analyte Specific Reagent

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