Thermo Fisher Scientific IL18BP Polyclonal Antibody
IL18BP 단백질을 표적으로 하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. Western blot, IHC, ICC/IF에 사용 가능. 인간 및 마우스 반응성. 고순도 항원 친화 크로마토그래피 정제. 연구용으로 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant full length Human IL18BP |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2719737 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. The purity is greater than 95% (by SDS-PAGE).
Target Information
Interleukin-18 binding protein (IL-18BP) is a constitutively secreted glycoprotein that acts as a natural antagonist for interleukin-18 (IL-18) by preventing its interaction with receptors. Through this binding, IL-18BP neutralizes the proinflammatory role of IL-18 in cell-mediated immune responses, resulting in reduced IFN-gamma production by T helper type I cells and inhibition of cytotoxic T lymphocyte (CTL) activity via enhanced NK cell cytotoxicity.
As an inhibitor of IL-18 and a key component of skin homeostasis, IL-18BP has been linked to diseases such as eczema, asthma, and Crohn’s disease. Upregulation of IL-18BP by keratinocytes expressing HPV E7 oncoprotein decreases IL-18-induced IFN-gamma production and T cell activation. Elevated IL-18 and IL-18BP levels, along with cytokines IFN-gamma, TNF-alpha, IL-1beta, and IL-8, are associated with chronic inflammation and observed in macrophages and intestinal tissues of Crohn’s disease patients.
IL-18BP is a member of the immunoglobulin-like receptor class and contains a single immunoglobulin (Ig) domain. Two of the four identified human isoforms (b and d) have incomplete domains, resulting in reduced binding affinity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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