Thermo Fisher Scientific TNFAIP6 Polyclonal Antibody

Thermo Fisher Scientific TNFAIP6 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

This antibody was affinity-purified from rabbit antiserum using epitope-specific immunogen. The purity is >95% as determined by SDS-PAGE.

Target Information

The TSG6 gene is transcribed in normal fibroblasts and activated by cytokines TNF-α and IL-1 at AP-1 and NF-IL6 promoter sites.
TSG-6 is a glycoprotein and a member of the hyaluronan-binding protein family, including cartilage link protein, proteoglycan core protein, and CD44.
It is highly homologous to CD44, particularly in the hyaluronic acid-binding domain.
TSG-6 expression is rapidly induced by TNF-α, IL-1, and lipopolysaccharide in normal fibroblasts, peripheral blood mononuclear cells, synovial cells, and chondrocytes.
Presence in synovial fluid suggests a role in rheumatoid arthritis.
TSG-6 forms a stable complex with inter-alpha-inhibitor (IαI) components and enhances its inhibitory effect on plasmin protease activity.
Together, TSG-6 and IαI modulate the protease network and help inhibit inflammation.

For Research Use Only. Not for use in diagnostic procedures or resale without express authorization.