Thermo Fisher Scientific AGPAT2 Polyclonal Antibody
AGPAT2 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, 인간 및 마우스 시료에 반응합니다. Western blot과 Immunocytochemistry에 사용 가능하며, 고순도 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용됩니다.
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Thermo Fisher Scientific AGPAT2 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | View 2 publications |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant full length Human AGPAT2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2719738 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. The purity is >95% (by SDS-PAGE).
Target Information
Lysophospholipid acyltransferases (LPLATs) catalyze the addition of fatty acyl moieties to the glycerol backbone of lysophospholipids. In addition to playing a crucial role in the synthesis of structural membrane components, LPLATs are also implicated in cellular signaling responses for cytokines, growth factors, and other agonists.
Cellular signaling through the interleukin 1 receptor in human mesangial cells and EL-4 cells proceeds by activation of lysophosphatidic acid acyltransferase (LPAAT). Activation of LPAAT by interleukin 1 results in the generation of unsaturated phosphatidic acid species, crucial for diacylglycerol and interleukin 1 signaling.
LPLATs are also involved in signaling for increased interleukin 2 synthesis through the T-cell antigen receptor. Activation of T-cells via anti-CD3 stimulation increases incorporation of polyunsaturated fatty acids into phosphatidylcholine via lysophosphatidylcholine acyltransferase. Activation of this enzyme is essential for sustained activation and translocation of protein kinase C.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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