Thermo Fisher Scientific AGPAT2 Polyclonal Antibody

Thermo Fisher Scientific AGPAT2 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

The antibody was affinity-purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. The purity is >95% (by SDS-PAGE).

Target Information

Lysophospholipid acyltransferases (LPLATs) catalyze the addition of fatty acyl moieties to the glycerol backbone of lysophospholipids. In addition to playing a crucial role in the synthesis of structural membrane components, LPLATs are also implicated in cellular signaling responses for cytokines, growth factors, and other agonists.

Cellular signaling through the interleukin 1 receptor in human mesangial cells and EL-4 cells proceeds by activation of lysophosphatidic acid acyltransferase (LPAAT). Activation of LPAAT by interleukin 1 results in the generation of unsaturated phosphatidic acid species, crucial for diacylglycerol and interleukin 1 signaling.

LPLATs are also involved in signaling for increased interleukin 2 synthesis through the T-cell antigen receptor. Activation of T-cells via anti-CD3 stimulation increases incorporation of polyunsaturated fatty acids into phosphatidylcholine via lysophosphatidylcholine acyltransferase. Activation of this enzyme is essential for sustained activation and translocation of protein kinase C.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.