Thermo Fisher Scientific alpha-2c Adrenergic Receptor Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100–1:500

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total Adrenergic Receptor alpha-2C.

Target Information

Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include three highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors regulate neurotransmitter release from sympathetic nerves and adrenergic neurons in the central nervous system. Studies in mice revealed that both alpha2A and alpha2C subtypes are required for normal presynaptic control of transmitter release. The alpha2A subtype inhibits transmitter release at high stimulation frequencies, while the alpha2C subtype modulates neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

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