Thermo Fisher Scientific CD134 (OX40) Monoclonal Antibody (ACT35 (ACT-35)), PE-Cyanine7, eBioscience
인간 CD134(OX40) 인식 단클론 항체로, 활성화된 T 세포 표면 단백질 분석에 적합. Flow Cytometry용으로 사전 희석되어 사용이 간편하며, PE-Cyanine7 형광체로 높은 감도 제공. 빛에 민감하므로 암조건에서 보관 필요.
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Thermo Fisher Scientific CD134 (OX40) Monoclonal Antibody (ACT35 (ACT-35)), PE-Cyanine7, eBioscience™
Applications and Tested Dilution
- Application: Flow Cytometry (Flow)
- Tested Dilution: 5 µL (0.5 µg)/test
- Publications: View 2 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), PE-Cyanine7, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | ACT35 (ACT-35) |
| Conjugate | PE-Cyanine7 |
| Excitation / Emission Max | 569 / 780 nm |
| Form | Liquid |
| Concentration | 5 µL/Test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE! |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2784661 |
Available Formats
Product Specific Information
The ACT35 monoclonal antibody reacts with human CD134 (OX-40), a 50 kDa type I membrane glycoprotein and member of the TNF receptor superfamily expressed by activated T lymphocytes.
CD134/OX-40 interaction with OX-40L is implicated in T cell-dependent humoral responses, regulation of T cell expansion and survival, memory T cell pool size, and tolerance in CD4⁺ T cells.
- Applications Reported: Flow cytometric analysis
- Applications Tested: Pre-diluted and validated for flow cytometry using stimulated human peripheral blood cells
- Recommended use: 5 µL (0.5 µg) per test
- A test = antibody amount for staining a sample in 100 µL final volume (10⁵–10⁸ cells/test)
Light Sensitivity:
Tandem dye sensitive to photo-induced oxidation; protect vial and stained samples from light.
Fixation:
Samples can be stored in IC Fixation Buffer (Product # 00-8222-49) or 1-step Fix/Lyse Solution (Product # 00-5333-57) for up to 3 days at 4°C in the dark with minimal effect on brightness and FRET efficiency.
Excitation / Emission / Laser:
- Excitation: 488–561 nm
- Emission: 775 nm
- Laser: Blue, Green, Yellow-Green
Target Information
OX40 is a receptor found on activated T cells, promoting their proliferation and survival. Activation of OX40 enhances immune responses against cancer and infectious agents.
OX40 agonists show promise in cancer immunotherapy, improving efficacy of chemotherapy and checkpoint inhibitors, and may have potential in autoimmune and allergic disease research.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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