Thermo Fisher Scientific INSIG1 Polyclonal Antibody
INSIG1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, 인간 및 생쥐 시료에 반응합니다. Western blot, IHC, ICC/IF 등 다양한 응용에 적합하며, 고순도 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- PA5100150
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human INSIG1 (Accession O15503), corresponding to amino acid residues W127–A177 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2815680 |
Product Specific Information
Antibody detects endogenous levels of total INSIG1.
Target Information
Oxysterols regulate cholesterol homeostasis through liver X receptor (LXR) and sterol regulatory element-binding protein (SREBP) mediated signaling pathway.
This gene is insulin-induced and encodes an endoplasmic reticulum (ER) membrane protein critical for regulating cholesterol concentrations in cells.
INSIG1 binds to sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, essential for sterol-mediated trafficking of these proteins.
Alternatively spliced transcript variants encoding distinct isoforms have been observed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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