Thermo Fisher Scientific NRP1 Monoclonal Antibody (3G6-2C5)

Applications

• ELISA (ELISA): Tested Dilution 10 µg/mL

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
RNDKCGDTIK IESPGYLTSP GYPHSYHPSE KCEWLIQAPD PYQRIMINFN PHFDLEDRDC KYDYVEVFDG ENENGHFRGK FCGKIAPPPV VSSGPFLFIK FVSDYETHGA GFSIRYEIFK RGPECSQNYT TPSGVIKSPG FPEKYPNSLE CTYIVFALKM SEIILEFESF DLEPDSNPPG GMFCRYDRLE IRDGFPDVGP HIGRYCGQKT PGRIRSSSGI LSMVFYTDSA IAKEGFSANY SVLQSSVSED FKCMEALGME SGEIHSDQIT ASSQYSTNWS AERSRLNYPE NGWTPGEDSY REWIQVDLGL LRFVTAVGTQ GAISKETKKK YYVKTYKIDV SSNGEDWITI KEGNKPVLFQ GNTNPTDVVV AVFPKPLITR FVRIKPATWE TGISMRFEVY GCKITDYPCS GMLGMVSGLI SDSQITSSNQ GDRNWMPENI RLVTSRSGWA LPPAPHSYIN EWLQIDLGEE KIVRGIIIQG GKHRENKVFM RKFKIGYSNN GSDWKMIMDD SKRKAKSFEG NNNYDTPELR TFPALSTRFI RIYPERATHG GLGLRMELLG CEVEAPTAGP TTPNGNLVDE CDDDQANCHS GTGDDFQLTG GTTVLATEKP TVIDSTIQSG IK

Target Information

Neuropilin 1 (NRP1) is a 923 amino acid membrane-bound coreceptor belonging to the neuropilin family. It contains two CUB domains, two F5/8 type C domains, and a MAM domain. NRP1 forms a heterodimer with NRP2 and binds to plexin (PLXNB1) to form semaphorin receptors. It is predominantly expressed in the nervous system and plays roles in cardiovascular development, angiogenesis, axon guidance, neuronal circuit formation, cell survival, neuronal migration, and organogenesis. Additionally, NRP1 acts as a receptor for semaphorins and VEGF, regulating VEGF-induced angiogenesis. It may be involved in aggressive prostate carcinoma and breast cancer progression.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.