Thermo Fisher Scientific NRP1 Monoclonal Antibody (3G6-2C5)

Applications

Tested Dilution

Publications

ELISA (ELISA)

10 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2a, kappa

Class

Monoclonal

Type

Antibody

Clone

3G6-2C5

Immunogen

NRP1 (AAH07533.1, 23 a.a. approximately 644 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Neuropilin 1 (CD304),uniProtId:O14786-1,ncbiNodeId:9606,antigenRange:1-923,antigenLength:923,antigenImageFileName:H00008829-M01_Neuropilin_1_CD304_O14786-1_House_mouse.svg,antigenImageFileNamePDP:H00008829-M01_Neuropilin_1_CD304_O14786-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: RNDKCGDTIK IESPGYLTSP GYPHSYHPSE KCEWLIQAPD PYQRIMINFN PHFDLEDRDC KYDYVEVFDG ENENGHFRGK FCGKIAPPPV VSSGPFLFIK FVSDYETHGA GFSIRYEIFK RGPECSQNYT TPSGVIKSPG FPEKYPNSLE CTYIVFALKM SEIILEFESF DLEPDSNPPG GMFCRYDRLE IRDGFPDVGP HIGRYCGQKT PGRIRSSSGI LSMVFYTDSA IAKEGFSANY SVLQSSVSED FKCMEALGME SGEIHSDQIT ASSQYSTNWS AERSRLNYPE NGWTPGEDSY REWIQVDLGL LRFVTAVGTQ GAISKETKKK YYVKTYKIDV SSNGEDWITI KEGNKPVLFQ GNTNPTDVVV AVFPKPLITR FVRIKPATWE TGISMRFEVY GCKITDYPCS GMLGMVSGLI SDSQITSSNQ GDRNWMPENI RLVTSRSGWA LPPAPHSYIN EWLQIDLGEE KIVRGIIIQG GKHRENKVFM RKFKIGYSNN GSDWKMIMDD SKRKAKSFEG NNNYDTPELR TFPALSTRFI RIYPERATHG GLGLRMELLG CEVEAPTAGP TTPNGNLVDE CDDDQANCHS GTGDDFQLTG GTTVLATEKP TVIDSTIQSG IK

Target Information

Neuropilin 1 is a 923 amino acid containing membrane bound coreceptor to a tyrosine kinase receptor belonging to the neuropilin family with two CUB domains, two F5/8 type C domains and a MAM domain. Neuropilin 1 forms a heterodimer with NRP2 (Neuropilin 2) and is known to bind to plexin (PLXNB1) to form semaphorin receptors. Expressed mostly in the nervous system this receptor is implicated in a wide range of functions including in the development of the cardiovascular system, angiogenesis, repulsive axon guidance, formation of certain neuronal circuits, cell survival, control of neuronal migration and organogenesis outside the nervous system. This semaphorin receptor functions as receptors for both the semaphorins and vascular endothelial growth factor and is also a regulator of VEGF-induced angiogenesis. Neuropilin 1 may be involved in aggressive advanced prostate carcinoma and in the progression of breast cancer.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.