Thermo Fisher Scientific NRP1 Monoclonal Antibody (3G6-2C5)

Applications

• ELISA

Tested Dilution: 10 µg/mL

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
RNDKCGDTIK IESPGYLTSP GYPHSYHPSE KCEWLIQAPD PYQRIMINFN PHFDLEDRDC KYDYVEVFDG ENENGHFRGK FCGKIAPPPV VSSGPFLFIK FVSDYETHGA GFSIRYEIFK RGPECSQNYT TPSGVIKSPG FPEKYPNSLE CTYIVFALKM SEIILEFESF DLEPDSNPPG GMFCRYDRLE IRDGFPDVGP HIGRYCGQKT PGRIRSSSGI LSMVFYTDSA IAKEGFSANY SVLQSSVSED FKCMEALGME SGEIHSDQIT ASSQYSTNWS AERSRLNYPE NGWTPGEDSY REWIQVDLGL LRFVTAVGTQ GAISKETKKK YYVKTYKIDV SSNGEDWITI KEGNKPVLFQ GNTNPTDVVV AVFPKPLITR FVRIKPATWE TGISMRFEVY GCKITDYPCS GMLGMVSGLI SDSQITSSNQ GDRNWMPENI RLVTSRSGWA LPPAPHSYIN EWLQIDLGEE KIVRGIIIQG GKHRENKVFM RKFKIGYSNN GSDWKMIMDD SKRKAKSFEG NNNYDTPELR TFPALSTRFI RIYPERATHG GLGLRMELLG CEVEAPTAGP TTPNGNLVDE CDDDQANCHS GTGDDFQLTG GTTVLATEKP TVIDSTIQSG IK

Target Information

Neuropilin 1 is a 923 amino acid membrane-bound coreceptor belonging to the neuropilin family with two CUB domains, two F5/8 type C domains, and a MAM domain. It forms a heterodimer with NRP2 and binds to plexin (PLXNB1) to form semaphorin receptors. Expressed mainly in the nervous system, this receptor is involved in cardiovascular development, angiogenesis, axon guidance, neuronal circuit formation, cell survival, neuronal migration, and organogenesis. It functions as a receptor for semaphorins and VEGF, regulating VEGF-induced angiogenesis. Neuropilin 1 may be implicated in advanced prostate and breast cancer progression.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.