Thermo Fisher Scientific AVEN Polyclonal Antibody
인간 AVEN 단백질에 반응하는 Rabbit Polyclonal Antibody. Western blot 및 IHC(P) 실험에 적합하며, 항원 친화 크로마토그래피로 정제됨. 액상 형태로 제공되며, 장기 보관 시 -20°C에서 안정적.
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Applications
Western Blot (WB)
- Tested Dilution: 0.04–0.4 µg/mL
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:200–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human AVEN. Recombinant protein control fragment (Product #RP-92081). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2789891 |
Product Specific Information
Immunogen sequence:
GPSRDSQKPT SPLQSAGDHL EEELDLLLNL DAPIKEGDNI LPDQTSQDLK SKEDGEVVQE EEVCAKPSVT EEKNMEPEQP STSK
Target Information
Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in various diseases such as cancer.
Aven is a recently discovered protein that blocks apoptosis induced by Apaf-1 and caspase-9. It is thought that Aven functions by binding to Bcl-xL, an antiapoptotic member of the Bcl-2 family, and to Apaf-1, possibly interfering with the ability of Apaf-1 to self-associate. This suggests that Aven impedes Apaf-1-mediated caspase activation.
Higher levels of Aven mRNA are seen in patients with acute leukemia than in control patients, suggesting that Aven may be useful as a prognostic indicator in leukemia patients.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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