Thermo Fisher Scientific Sclerostin Monoclonal Antibody (220902)
인간 Sclerostin 단백질을 인식하는 Mouse IgG2b 단일클론 항체. Western blot, ELISA, IHC 등 다양한 응용에 적합. 단백질 A/G로 정제된 동결건조 형태로 제공되며, PBS + 5% trehalose 버퍼에 재구성 가능. 연구용으로만 사용.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1 µg/mL | View 2 publications |
| Immunohistochemistry (IHC) | - | View 1 publication |
| ELISA | 0.5–2 µg/mL (Detection), 2–8 µg/mL (Capture) | View publications |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human, Mouse |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 220902 |
| Immunogen | Mouse myeloma cell line NS0-derived recombinant human SOST/Sclerostin (Gln24–Tyr213) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.5 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2605787 |
Product Specific Information
- No cross-reactivity with recombinant mouse SOST observed in direct ELISA and Western blot.
- Reconstitute at 0.5 mg/mL in sterile PBS.
Target Information
Sclerostin is a glycoprotein mainly secreted by osteocytes and belongs to the Cerberus/DAN family of BMP antagonists. It acts as an endogenous regulator of the canonical Wnt signaling pathway and plays a key role in bone homeostasis.
Though primarily expressed by osteocytes, sclerostin is also found in bone, bone marrow, cartilage, kidney, and liver, and produced by hypertrophic chondrocytes and cementocytes.
It interacts with LRP5, LRP6, and LRP4 to inhibit Wnt signaling and can promote osteoclast activity via RANKL expression.
Mutations causing reduced sclerostin levels lead to bone overgrowth disorders such as sclerosteosis and van Buchem disease (VBD).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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