Thermo Fisher Scientific DAXX Monoclonal Antibody (4C2)
DAXX 단백질을 인식하는 Thermo Fisher Scientific의 Mouse Monoclonal Antibody(4C2). Western blot, ICC/IF, ELISA, PLA 등 다양한 응용에 적합. Human 시료 반응성, PBS 기반 액상 형태, 보존제 없음, -20°C 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| ELISA | 1 ng/mL |
| in situ PLA (PLA) | 1:1200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4C2 |
| Immunogen | DAXX (NP_001341, 561–660 a.a.) partial recombinant protein with GST tag (MW of GST tag: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Protein Sequence:
SPVSQLFELE IEALPLDTPS SVETDISSSR KQSEEPFTTV LENGAGMVSS TSFNGGVSPH NWGDSGPPCK KSRKEKKQTG SGPLGNSYVE RQRSVHEKNG
Target Information
This gene encodes a multifunctional protein that resides in both the nucleus and cytoplasm. It interacts with various proteins, including apoptosis antigen Fas, centromere protein C, and transcription factor E26 oncogene homolog 1.
In the nucleus, it functions as a potent transcription repressor binding to sumoylated transcription factors. Its repression can be relieved by sequestration into promyelocytic leukemia nuclear bodies or nucleoli.
The protein associates with centromeres in G2 phase and may regulate apoptosis in the cytoplasm. Localization and function are modulated by post-translational modifications such as sumoylation, phosphorylation, and polyubiquitination.
Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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