Thermo Fisher Scientific DAZ1 Monoclonal Antibody (3E3)
Human DAZ1 단백질을 인식하는 Mouse IgG1 단클론 항체로, Western blot, IHC, ELISA에 적합. Affinity chromatography로 정제된 액상 형태이며, PBS(pH 7.4)에 보존제 없이 공급. 연구용으로 정자형성 관련 DAZ1 단백질 분석에 활용 가능.
- 카탈로그번호
- H00001617-M06
- 판매단위
- pk
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1 µg/mL |
| ELISA | 0.1 ng/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3E3 |
| Immunogen | DAZ1 (AAH18119, 21–120 a.a.) partial recombinant protein with GST tag (MW of GST tag alone: 26 KDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
SSSAAASQGW VLPEGKIVPN TVFVGGIDAR MDETEIGSCF GRYGSVKEVK IITNRTGVSK GYGFVSFVND VDVQKIVGSQ IHFHGKKLKL GPAIRKQKLC
Target Information
This gene is a member of the DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor.
Its expression is restricted to premeiotic germ cells, particularly in spermatogonia.
It encodes an RNA-binding protein important for spermatogenesis.
Four copies of this gene are found on chromosome Y within palindromic duplications; one pair of genes is part of the P2 palindrome, and the second pair is part of the P1 palindrome.
Each gene contains a 2.4 kb repeat including a 72-bp exon called the DAZ repeat; the number and sequence of DAZ repeats vary.
Each copy also contains a 10.8 kb region that may be amplified, including five exons encoding an RNA recognition motif (RRM) domain.
Although three copies of the 10.8 kb repeat exist, transcripts with three RRM domains have not been described—thus the RefSeq for this gene contains only two RRM domains.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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