Thermo Fisher Scientific UBR4 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 4884-5183 of human UBR4 (NP_0658162) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:UBR4,uniProtId:Q5T4S7-1,ncbiNodeId:9606,antigenRange:4884-5183,antigenLength:5183,antigenImageFileName:PA5-88406_UBR4_Q5T4S7-1_Rabbit.svg,antigenImageFileNamePDP:PA5-88406_UBR4_Q5T4S7-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

2.34 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2804889

Product Specific Information

Immunogen sequence: NIVHYDCHLA AVRLARGREE WESAALQNAN TKCNGLLPVW GPHVPESAFA TCLARHNTYL QECTGQREPT YQLNIHDIKL LFLRFAMEQS FSADTGGGGR ESNIHLIPYI IHTVLYVLNT TRATSREEKN LQGFLEQPKE KWVESAFEVD GPYYFTVLAL HILPPEQWRA TRVEILRRLL VTSQARAVAP GGATRLTDKA VKDYSAYRSS LLFWALVDLI YNMFKKVPTS NTEGGWSCSL AEYIRHNDMP IYEAADKALK TFQEEFMPVE TFSEFLDVAG LLSEITDPES FLKDLLNSVP; Positive Samples: HeLa; Cellular Location: Cytoplasm, Membrane, Multi-pass membrane protein, Nucleus, cytoskeleton

Target Information

E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions. Mediates ubiquitination of ACLY, leading to its subsequent degradation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.