Thermo Fisher Scientific WSB1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

ELISA

• Tested Dilution: 1 µg/mL

Product Specifications

Product Specific Information

Immunogen sequence:

GSLILVSASR DKTLRVWDLK DDGNMMKVLR GHQNWVYSCA FSPDSSMLCS VGASKAVFLW NMDKYTMIRK LEGHHHDVVA CDFSPDGALL ATASYDTRVY IWDPHNGDIL MEFGHLFPPP TPIFAGGAND RWVRSVSFSH DGLHVASLAD DKMVRFWRID EDYPVQVAPL SNGLCCAFST DGSVLAAGTH DGSVYFWATP RQVPSLQHLC RMSIRRVMPT QEVQELPIPS KLLEFLSYRI

Positive Samples: HT-29, A-549, HeLa, HepG2, SGC-7901

Target Information

WSB1 (WD repeat and SOCS box-containing 1), also known as SWIP1, is a 421 amino acid protein that contains one SOCS box domain and six WD repeats. It is expressed as multiple alternatively spliced isoforms and is thought to function as part of an SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins such as DIO2. Overexpression of WSB1 has been implicated in pancreatic cancer progression, suggesting a role in carcinogenesis.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.