Thermo Fisher Scientific WSB1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 182-421 of human WSB1 (NP_0564416) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:WSB1,uniProtId:Q9Y6I7-1,ncbiNodeId:9606,antigenRange:182-421,antigenLength:421,antigenImageFileName:PA5-88407_WSB1_Q9Y6I7-1_Rabbit.svg,antigenImageFileNamePDP:PA5-88407_WSB1_Q9Y6I7-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.01% thimerosal

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2804890

Product Specific Information

Immunogen sequence: GSLILVSASR DKTLRVWDLK DDGNMMKVLR GHQNWVYSCA FSPDSSMLCS VGASKAVFLW NMDKYTMIRK LEGHHHDVVA CDFSPDGALL ATASYDTRVY IWDPHNGDIL MEFGHLFPPP TPIFAGGAND RWVRSVSFSH DGLHVASLAD DKMVRFWRID EDYPVQVAPL SNGLCCAFST DGSVLAAGTH DGSVYFWATP RQVPSLQHLC RMSIRRVMPT QEVQELPIPS KLLEFLSYRI; Positive Samples: HT-29, A-549, HeLa, HepG2, SGC-7901

Target Information

WSB1 (WD repeat and SOCS box-containing 1), also known as SWIP1, is a 421 amino acid protein that contains one SOCS box domain and six WD repeats. Expressed as multiple alternatively spliced isoforms, WSB1 is thought to function as part of an SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as DIO2. Overexpression of WSB1 is implicated in pancreatic cancer progression, suggesting a role for WSB1 in carcinogenesis.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.