Thermo Fisher Scientific TrkB Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

• Glycerol (1:1) may be added for additional stability.
• Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
• The peptide is homologous in rat and mouse.

Target Information

NTRK2 (TrkB) belongs to the neurotrophic factor family of related polypeptides central to the development and maintenance of the mammalian nervous system. NTRK2 is the receptor for brain-derived neurotrophic factor (BDNF). Together, NTRK2 and BDNF regulate both short-term synaptic functions and long-term potentiation of brain synapses.

TrkB is involved in the development and maintenance of the nervous system and is a tyrosine kinase gene highly related to TrkA. Its expression is confined to tissues within the central and peripheral nervous systems. BDNF and NT-3, but not NGF, can induce rapid tyrosine phosphorylation of TrkB gp145, one of the receptors encoded by TrkB, with BDNF eliciting a response at least two orders of magnitude greater than NT-3.

TrkB is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signaling through TrkB leads to cell differentiation. Mutations in the TrkB gene have been associated with obesity and mood disorders. Alternate transcriptional splice variants encoding different isoforms have been found for the TrkB gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.