Thermo Fisher Scientific TrkB Polyclonal Antibody
Rabbit polyclonal antibody targeting human TrkB (NTRK2) receptor. Suitable for WB and IHC at 1:1,000 dilution. Lyophilized form for long-term storage at -20°C. Recognizes TrkB involved in neurotrophic signaling and synaptic function. For research use o...
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | - |
| Immunohistochemistry (IHC) | 1:1,000 | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from human TrkB conjugated to blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity: TrkB.
Target Information
Gene: NTRK2 (TRKB)
Function: NTRK2 encodes the receptor for brain-derived neurotrophic factor (BDNF), a key regulator of neuronal development and maintenance. Together, NTRK2 and BDNF influence short-term synaptic functions and long-term potentiation.
TrkB is a tyrosine kinase receptor expressed primarily in central and peripheral nervous system tissues. BDNF and NT-3 induce phosphorylation of TrkB, activating MAPK signaling and promoting cell differentiation.
Mutations in TrkB have been linked to obesity and mood disorders. Multiple splice variants encoding different isoforms exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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