Thermo Fisher Scientific HEY1 Monoclonal Antibody (2F10)
HEY1 단백질을 인식하는 마우스 단클론 항체(클론 2F10)로, Western blot 및 ELISA에 적합합니다. 인간 시료에 반응하며, PBS 용액 상태로 제공됩니다. Notch 신호전달 관련 연구 및 전사 억제 기전 분석에 유용합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| ELISA | 0.1 ng/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2F10 |
| Immunogen | HEY1 (NP_036390, 121–220 a.a.) partial recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Protein sequence:
DYRSLGFREC LAEVARYLSI IEGLDASDPL RVRLVSHLNN YASQREAASG
AHAGLGHIPW GTVFGHHPHI AHPLLLPQNG HGNAGTTASP TEPHHQGRLGTarget Information
Hairy/enhancer-of-split related with YRPW motif protein 1 (HEY1) belongs to the HEY family and is a Notch signaling pathway protein.
It contains one basic helix-loop-helix (bHLH) domain and one Orange domain.
HEY1 acts as a transcriptional repressor binding preferentially to the canonical E-box sequence (5'-CACGTG-3'), repressing transcription by cardiac activators GATA4 and GATA6.
It plays a role in cardiovascular and nervous system development as a downstream effector of Notch signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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