Thermo Fisher Scientific TAB3 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:32,000.

Target Information

TAB3 functions in the NF-κB signal transduction pathway. It, along with the similar and functionally redundant protein TAB2, forms a ternary complex with the protein kinase TAK1 and either TRAF2 or TRAF6 in response to stimulation with pro-inflammatory cytokines TNF or IL-1. Subsequent TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-κB transcription factor.
Recent experiments have shown that TAB2 and the related protein TAB3 constitutively interact with the autophagy mediator Beclin-1; upon induction of autophagy, these proteins dissociate from Beclin-1 and bind TAK1. Overexpression of TAB2 and TAB3 inhibits autophagy, while their depletion triggers it, suggesting that TAB2 and TAB3 act as a control point for autophagy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.