Thermo Fisher Scientific IL8 Monoclonal Antibody (1G9)

Applications and Tested Dilution

Product Specifications

Product Specific Information

Protein sequence:
EGAVLPRSAK ELRCQCIKTY SKPFHPKFIK ELRVIESGPH CANTEIIVKL SDGRELCLDP KENWVQRVVE KFLKRAENS

Target Information

Interleukin 8 (IL-8, CXCL8) is a 72 amino acid pro-inflammatory factor belonging to the CXC subfamily of chemokines. It binds to cell surface receptors IL-8RA and IL-8RB, functioning as a chemoattractant and potent angiogenic factor. IL-8 expression and secretion are induced by various inflammatory stimuli in many cells, including macrophages and endothelial cells. In endothelial cells, IL-8 is stored in Weibel-Palade bodies.
Originally isolated from osteosarcoma cells, IL-8 contains the ELR motif (N-terminal Glu-Leu-Arg) and signals through CXCR1 and CXCR2 receptors. Previous names include neutrophil activating protein 1 (NAP-1), granulocyte chemotactic protein 1 (GCP-1), monocyte-derived neutrophil-activating peptide (MONAP), and protein 3-10C.
IL-8 and other CXC chemokine family members form a gene cluster on chromosome 4q. Studies show IL-8 plays a role in tumor angiogenesis and growth, and in the pathogenesis of bronchiolitis, a viral respiratory disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.