Thermo Fisher Scientific IL8 Monoclonal Antibody (4E3)
인간 IL-8 단백질을 인식하는 마우스 모노클로날 항체로, Western blot, ELISA, Immunoprecipitation에 적합합니다. 비결합형 액상 형태이며 PBS 버퍼에 보존됩니다. 연구용으로만 사용되며 IL-8 관련 염증 및 종양 연구에 활용 가능합니다.
- 카탈로그번호
- H00003576-M18
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific IL8 Monoclonal Antibody (4E3)
Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| ELISA | 10 µg/mL |
| Immunoprecipitation (IP) | 1–5 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4E3 |
| Immunogen | IL8 (AAH13615, 21 a.a. approximately 99 a.a) full length recombinant protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
EGAVLPRSAK ELRCQCIKTY SKPFHPKFIK ELRVIESGPH CANTEIIVKL SDGRELCLDP KENWVQRVVE KFLKRAENS
Target Information
Interleukin 8 (IL-8, CXCL8) is a 72 amino acid pro-inflammatory factor belonging to the CXC subfamily of chemokines. It binds to cell surface receptors IL-8RA and IL-8RB and functions as a chemoattractant and potent angiogenic factor.
IL-8 expression and secretion can be induced by diverse inflammatory stimuli in many cells, including macrophages and endothelial cells. In endothelial cells, IL-8 is stored in Weibel-Palade bodies.
Originally isolated from osteosarcoma cells, IL-8 contains the ELR-motif (N-terminal Glu-Leu-Arg sequence) and signals through CXCR1 and CXCR2 receptors.
Previous nomenclature includes neutrophil activating protein 1 (NAP-1), granulocyte chemotactic protein 1 (GCP-1), monocyte-derived neutrophil-activating peptide (MONAP), and protein 3-10C.
IL-8 and ten other members of the CXC chemokine gene family form a gene cluster on chromosome 4q.
Cancer studies have shown IL-8’s role in angiogenesis and tumor growth, and it is implicated in the pathogenesis of bronchiolitis caused by viral infection.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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