Thermo Fisher Scientific ARAP1 Monoclonal Antibody (ARAP1-2)

Applications

Tested Dilution

Publications

Western Blot (WB)

2 µg/mL

-

Immunocytochemistry (ICC/IF)

Assay-dependent

-

Immunoprecipitation (IP)

Assay-dependent

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

ARAP1-2

Immunogen

His6-tagged protein corresponding to amino acids 1190-1450 of human ARAP1. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:ARAP1,uniProtId:Q96P48-6,ncbiNodeId:9606,antigenRange:1190-1450,antigenLength:1450,antigenImageFileName:MA1-19728_ARAP1_Q96P48-6_House_mouse.svg,antigenImageFileNamePDP:MA1-19728_ARAP1_Q96P48-6_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.4

Contains

15mM sodium azide

Storage conditions

4° C, do not freeze

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2227584

Product Specific Information

This antibody reacts with C-terminal part of ARAP1 (intracellular epitope), a 160 kDa adaptor protein.

Target Information

ARAP1 (angiotensin II type 1 receptor-associated protein) is an adaptor protein with ArfGAP and RhoGAP activities, containing five PH domains and ankyrin repeat. This adaptor seems to serve as a link between phosphoinositide- Arf-, and Rho-mediated cell signaling. ARAP1 supports the plasma membrane recycling of angiotensin II type 1 receptor (AT1) and is important also for cell-specific trafficking of pro-death receptor TRAIL-R1 (DR4) to the plasma membrane, thus promoting the TRAIL-induced apoptosis in certain cell types. ARAP1 also affects cell spreading.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.