Thermo Fisher Scientific ARAP1 Monoclonal Antibody (ARAP1-2)
ARAP1 단백질의 C-말단 부위를 인식하는 mouse monoclonal 항체로, Western blot, ICC/IF, IP에 사용 가능. Human 시료에 반응하며, Protein A로 정제된 액상 형태. PBS 완충액(15mM sodium azide 포함) 보관, 4°C에서 안정적.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 2 µg/mL |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | ARAP1-2 |
| Immunogen | His6-tagged protein corresponding to amino acids 1190–1450 of human ARAP1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2227584 |
Product Specific Information
This antibody reacts with the C-terminal part of ARAP1 (intracellular epitope), a 160 kDa adaptor protein.
Target Information
ARAP1 (angiotensin II type 1 receptor-associated protein) is an adaptor protein with ArfGAP and RhoGAP activities, containing five PH domains and ankyrin repeats. It serves as a link between phosphoinositide-, Arf-, and Rho-mediated cell signaling. ARAP1 supports plasma membrane recycling of the angiotensin II type 1 receptor (AT1) and is important for cell-specific trafficking of the pro-death receptor TRAIL-R1 (DR4) to the plasma membrane, promoting TRAIL-induced apoptosis in certain cell types. ARAP1 also affects cell spreading.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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