Thermo Fisher Scientific GLTSCR2 Polyclonal Antibody
Human GLTSCR2 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P) 및 ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, 0.1 mg/mL 농도의 액상 형태. 세포 내 p53 활성 조절 및 리보솜 생합성 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human GLTSCR2 (Recombinant protein control fragment: Product #RP-92581) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2642052 |
Product Specific Information
Immunogen sequence:
REAEADKPRR LGRLKYQAPD IDVQLSSELT DSLRTLKPEG NILRDRFKSF QRRNMIEPRE RAKFKRKYKV KLVEKRAFRE IQL
Antigen sequence identity:
- Mouse: 93%
- Rat: 95%
Target Information
GLTSCR2 (also known as NOP53) is a nucleolar protein involved in integrating the 5S RNP into the ribosomal large subunit during ribosome biogenesis. It may also participate in rRNA transcription and act as a nucleolar sensor regulating p53/TP53 activation in response to ribosome biogenesis perturbation, DNA damage, and other stress conditions.
Disruption of the NOP53–RPL11 interaction allows RPL11 transport to the nucleoplasm, inhibiting MDM2 and activating p53/TP53. GLTSCR2 may also enhance p53-mediated cell cycle arrest and apoptosis by preventing MDM2-dependent degradation. Identified as a tumor suppressor, it stabilizes PTEN, antagonizing the PI3K-AKT signaling pathway, and may inhibit cell proliferation through interaction with NF2. Additionally, it regulates NPM1 localization and degradation, thereby modulating MYC–NPM1-mediated transcription. GLTSCR2 may also influence cellular aerobic respiration and attenuate interferon-beta response via DDX58/RIG-1 inhibition.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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