Thermo Fisher Scientific TCR V alpha 11 Chimeric Recombinant Rabbit Monoclonal Antibody (34)

Applications and Tested Dilution

Product Specifications

Product Specific Information

Specificity: This antibody binds to the T-cell receptor alpha chains.

Target Information

The T-cell receptor (TCR) plays a critical role in the adaptive immune response by distinguishing foreign from self-peptides presented by MHC class II molecules. Recognition of self-peptides can be associated with autoimmune diseases, while mutant self-peptides have been linked to tumors. Superantigen engagement of TCRs is implicated in toxic shock syndrome.

Autoantibodies targeting V beta segments of TCRs have been identified in rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), where they may modulate TH1-mediated inflammatory responses. Most human T cells express TCR alpha-beta along with CD4 or CD8, while a small subset lacks both (double negative, DN). Elevated levels of alpha-beta DN T cells are observed in certain autoimmune and immunodeficiency conditions. Gamma-delta T cells, primarily found in epithelial tissues, exhibit limited TCR diversity and distinct antigen recognition, with subsets showing antitumor and immunoregulatory functions.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.