Thermo Fisher Scientific Phospho-Progesterone Receptor (Ser190) Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

This antibody detects endogenous levels of Progesterone Receptor only when phosphorylated at Ser190.

Target Information

The progesterone receptor (PR) is a member of the steroid family of nuclear receptors. PR mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. PR exists as two forms: a 94 kDa protein (Form A) and a 120 kDa protein (Form B), resulting from alternative translation initiation sites. PR-B is transcriptionally active and responsible for activating genes involved in endometrial maintenance, pregnancy, and ovulation inhibition. PR-A lacks 165 amino acids at the N-terminus compared to PR-B, exposing a 140 amino acid inhibitory domain that represses steroid hormone transcriptional activity. In its inactive state, PgR forms a multiprotein complex including heat shock proteins and immunophilins. Upon progesterone binding, the receptor undergoes a conformational change, enabling dimerization and binding to progesterone response elements (PRE), leading to activated transcription. A null mutation in the PGR gene leads to pleiotropic reproductive abnormalities.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.