Thermo Fisher Scientific PAG1 Polyclonal Antibody
Rabbit 유래의 PAG1 단백질에 특이적인 다클론 항체로, 인간 PAG1 단백질을 인식합니다. 액상 형태로 제공되며, 단기 보관은 4°C, 장기 보관은 -20°C에서 권장됩니다. 연구용으로만 사용 가능합니다.
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- PA584729
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- pk
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Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human PAG1 (UniProt ID: Q9NWQ8-1, antigen range: 126-204, antigen length: 432) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2791879 |
Product Specific Information
Immunogen sequence:
KCHQSRELPR IPPESAVDTM LTARSVDGDQ GLGMEGPYEV LKDSSSQENM VEDCLYETVK EIKEVAAAAH LEKGHSGKA
Target Information
PAG (phosphoprotein associated with GEMs), also known as Cbp (Csk-binding protein), is a ubiquitously expressed 46 kDa transmembrane adaptor protein present in membrane rafts (glycosphingolipid-enriched microdomains), which migrates on SDS PAGE gels anomalously as an 80 kDa molecule. Following tyrosine phosphorylation by Src family kinases, PAG binds and activates the protein tyrosine kinase Csk, a major negative regulator of the Src family kinases.
Signaling via the B-cell receptor in B cells or the high affinity IgE receptor (FcepsilonRI) in mast cells leads to increased tyrosine phosphorylation of PAG and Csk binding, while T cell receptor signaling causes PAG dephosphorylation, loss of Csk binding, and increased activation of the protein tyrosine kinase Lck.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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