Thermo Fisher Scientific PAG1 Polyclonal Antibody

Product Specifications

Product Specific Information

Immunogen sequence:
KCHQSRELPR IPPESAVDTM LTARSVDGDQ GLGMEGPYEV LKDSSSQENM VEDCLYETVK EIKEVAAAAH LEKGHSGKA

Target Information

PAG (phosphoprotein associated with GEMs), also known as Cbp (Csk-binding protein), is a ubiquitously expressed 46 kDa transmembrane adaptor protein present in membrane rafts (glycosphingolipid-enriched microdomains), which migrates on SDS PAGE gels anomalously as an 80 kDa molecule. Following tyrosine phosphorylation by Src family kinases, PAG binds and activates the protein tyrosine kinase Csk, a major negative regulator of the Src family kinases.
Signaling via the B-cell receptor in B cells or the high affinity IgE receptor (FcepsilonRI) in mast cells leads to increased tyrosine phosphorylation of PAG and Csk binding, while T cell receptor signaling causes PAG dephosphorylation, loss of Csk binding, and increased activation of the protein tyrosine kinase Lck.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.