Thermo Fisher Scientific RIM2 Polyclonal Antibody
Human RIMS2 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P)에서 1:1,000–1:2,500 희석 비율로 사용 가능. 항원 친화 크로마토그래피로 정제된 액상 형태이며, 신경 전달 및 시냅스 기능 연구용으로 적합. 연구용 전용 제품.
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Applications
Immunohistochemistry (Paraffin) [IHC (P)]
- Tested Dilution: 1:1,000–1:2,500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human RIMS2. Recombinant protein control fragment (Product #RP-107501) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2791875 |
Product Specific Information
Immunogen sequence:
MDIEERNRQM KINKYKQVAG SDPRLEQDYH SKYRSGWDPH RGADNVSTKS S
Target Information
Rab3-interacting molecules (RIMs) are synaptic proteins necessary for neuronal transmission and plasticity. Rim1 and Rim2 proteins are expressed in overlapping but distinct patterns throughout the brain. While the ablation of either gene was not lethal in mice, the deletion of both resulted in postnatal mortality due to a defect in neurotransmitter release. Synapses lacking RIM proteins can still release neurotransmitters but fail to respond to normal Ca²⁺ triggers. Like Rim1, Rim2 functions as an effector protein for Rab3, binding to Rab3 on synaptic vesicles in a GTP-dependent manner.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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