Thermo Fisher Scientific CSNK1E Monoclonal Antibody (OTI2B3), TrueMAB
Human CSNK1E 단백질(aa 153-416)에 특이적인 Mouse IgG1 단클론 항체로, Western blot에 최적화되어 있음. 무보존제, 동결건조 형태로 제공되며 재구성 후 1 mg/mL 농도 유지. 세포 신호전달 및 신경퇴행성 질환 연구에 적합.
- 판매단위
- pk
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Applications
- Western Blot (WB): Tested dilution 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2B3 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 153–416 of human CSNK1E produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
CSNK1E (CK1 epsilon) is a serine/threonine kinase involved in diverse cellular processes, including vesicular trafficking, DNA damage repair, cell cycle progression, and cytokinesis.
It phosphorylates key regulatory proteins controlling cell differentiation, proliferation, chromosome segregation, circadian rhythms, and metabolic pathways.
CK1 family members share a conserved kinase domain but differ in their variable N- and C-terminal regions. Mammals possess seven family members: alpha, beta, gamma1, gamma2, gamma3, delta, and epsilon.
CK1ε positively regulates Akt by inhibiting PP2A and plays a significant role in neurodegenerative disease mechanisms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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