Thermo Fisher Scientific ITGB1BP1 Monoclonal Antibody (OTI1D10), TrueMAB
인간 ITGB1BP1 단백질을 인식하는 Mouse IgG2a 단일클론 항체. Western blot에 최적화되어 있으며, 동결건조 형태로 제공. PBS(8% trehalose) 버퍼에 보존되고, -20°C에서 보관 권장. 세포 부착 및 신호전달 연구용으로 적합.
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Applications and Tested Dilution
- Western Blot (WB): 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1D10 |
| Immunogen | Full length human recombinant protein of human ITGB1BP1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
ITGB1BP1 is a key regulator of integrin-mediated cell-matrix signaling by binding to the ITGB1 cytoplasmic tail and preventing activation of integrin α5β1 by talin or FERMT1.
It plays roles in:
- Cell proliferation, differentiation, adhesion, and migration
- Bone mineralization and angiogenesis
- Regulation of β1 integrin-containing focal adhesion dynamics
- Modulation of Rho family GTPases (CDC42, RAC1)
- Promoting AKT phosphorylation and inhibiting ERK1/2 phosphorylation via Notch pathway activation
- Enhancing MYC promoter transcriptional activity
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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