Thermo Fisher Scientific PPP6C Polyclonal Antibody
PPP6C 단백질을 인식하는 Thermo Fisher Scientific의 다클론 항체로, WB 및 IP 등 다양한 분석에 사용 가능. 인간, 생쥐, 소, 랫트 반응성. 합성 펩타이드 면역원, 액상 형태, -20°C 보관. 연구용으로 DNA 복구 및 단백질 인산화 연구에 적합.
- 카탈로그번호
- PA112400
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific PPP6C Polyclonal Antibody
Applications
- Western Blot (WB): Assay-dependent
- Immunoprecipitation (IP): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bovine, Human, Mouse, Rat |
| Host / Isotype | Sheep / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | PBS |
| Contains | 0.08% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1086921 |
Target Information
Distinct DNA repair pathways minimize the consequences of mutagenic events. Reactive oxygen species (ROS) are highly reactive atoms with an unpaired electron that are conducive to double-strand DNA breaking events. Artemis, named after the Greek goddess for the protection of children, is one of the major proteins contributing to the preservation of double-strand breaks in DNA by cutting away the damaged parts of the DNA, which allows the strands to rejoin. Artemis is a single-strand-specific 5' to 3' exonuclease that forms a complex with the 469 kDa DNA-dependent protein kinase (DNA-PKcs). DNA-PKcs phosphorylates Artemis, and Artemis acquires endonucleolytic activity on 5' and 3' overhangs and hairpins. These activities are essential for V(D)J recombination and for the 5' and 3' overhang processing in nonhomologous DNA end joining.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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