Thermo Fisher Scientific PPP6C Polyclonal Antibody
PPP6C 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, IP 등 다양한 연구용 응용에 적합. Bovine, Human, Mouse, Rat 반응성. 고순도 정제 및 안정적 PBS 저장. DNA 복구 관련 연구에 활용 가능.
- 카탈로그번호
- PA112399
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific PPP6C Polyclonal Antibody
Applications
- Western Blot (WB): Assay-dependent
- Immunohistochemistry (IHC): Assay-dependent
- Immunoprecipitation (IP): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bovine, Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | PBS |
| Contains | 0.08% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1086920 |
Target Information
Distinct DNA repair pathways minimize the consequences of mutagenic events. Reactive oxygen species (ROS) are highly reactive atoms with an unpaired electron that can induce double-strand DNA breaks. Artemis, named after the Greek goddess for the protection of children, is a major protein contributing to the preservation of double-strand breaks in DNA by removing damaged parts, allowing the strands to rejoin.
Artemis acts as a single-strand-specific 5′ to 3′ exonuclease forming a complex with the 469 kDa DNA-dependent protein kinase (DNA-PKcs). DNA-PKcs phosphorylates Artemis, enabling endonucleolytic activity on 5′ and 3′ overhangs and hairpins. These functions are essential for V(D)J recombination and nonhomologous DNA end joining.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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