Thermo Fisher Scientific STRAP Polyclonal Antibody
STRAP 단백질을 인식하는 Rabbit Polyclonal Antibody로 인간 및 생쥐 시료에 반응합니다. Western blot 및 Immunoprecipitation에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 4°C에서 보관하며 연구용으로 사용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–10 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 300–350 of Human Serine/Threonine Kinase Receptor Associated Protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Phosphate/Tris citrate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
STRAP is a 350 amino acid MAP activator with WD-40 repeats localized in both cytoplasm and nucleus. It acts as an inhibitor of TGF-beta signaling and regulates cell proliferation. Stable expression activates the MAPK/ERK pathway and down-regulates p21 (Cip1), leading to retinoblastoma protein hyperphosphorylation. Upregulation of STRAP may contribute to early tumor development, particularly in colorectal cancer. It is also a key component in U snRNP assembly associated with the SMN complex, influencing intracellular SMN1 distribution.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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