Thermo Fisher Scientific Axl Polyclonal Antibody
Human AXL 단백질에 특이적인 Rabbit Polyclonal Antibody로, WB, IHC, Flow Cytometry에 적합합니다. KLH 결합 합성 펩타이드(13–44 aa)를 면역원으로 사용하며, 비결합 형태의 액상 제품입니다. 암 연구 및 세포 신호전달 연구용으로 적합합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
| Flow Cytometry (Flow) | 1:10–1:50 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 13–44 amino acids from the N-terminal region of human AXL |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation, Size-exclusion, Dialysis |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2062555 |
Target Information
AXL is a chronic myelogenous leukemia-associated oncogene also linked to colon cancer and melanoma.
The AXL protein is a receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factors such as vitamin K-dependent protein GAS6, stimulating cell proliferation.
TAM receptors, including AXL, are involved in phagocytosis of apoptotic cells. Mice lacking TAM receptors exhibit degenerative phenotypes and autoimmune responses similar to systemic lupus erythematosus.
AXL may also function as an entry receptor for filoviruses and is a marker for Siglec 6+/Axl+ dendritic cells. Cellular expression can be upregulated by TLR ligands (LPS, poly I:C), and soluble AXL levels may indicate inflammation or cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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