Thermo Fisher Scientific POLH Polyclonal Antibody
Thermo Fisher Scientific의 POLH Polyclonal Antibody는 인간 POLH 단백질을 인식하는 토끼 유래 IgG 항체로, Western blot 및 IHC(P) 실험에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS 버퍼에 보존되어 안정적인 연구용 시약입니다.
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Applications
Western Blot (WB)
- Tested Dilution: 0.04–0.4 µg/mL
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:200–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human POLH. Recombinant protein control fragment (Product #RP-89495). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2645750 |
Product Specific Information
Immunogen sequence:
ERASIDEAYV DLTSAVQERL QKLQGQPISA DLLPSTYIEG LPQGPTTAEE TVQKEGMRKQ GLFQWLDSLQ IDNLTSPDLQ LTVGAVIVEE MRAAIERETG FQCSAGISHN KVLAKLACGL NKPNRQTLVS HGSVPQLFSQ MPIRKIRSL
Highest antigen sequence identity to the following orthologs:
- Mouse: 91%
- Rat: 87%
Target Information
The XPA gene encodes a zinc metalloprotein that preferentially binds to DNA damaged by UV radiation and chemical carcinogens and is required for the incision step during nucleotide excision repair.
The XPB and XPD genes encode DNA helicases involved in several DNA metabolic pathways, including DNA repair and transcription.
The XPG gene product is an endonuclease that cuts on the 3′ side of a DNA lesion during nucleotide excision repair.
Molecular defects in the XP variant (POLH) group maintain normal excision repair yet result in a substantial reduction in the ability to synthesize intact daughter DNA strands during DNA replication following DNA damage.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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