Thermo Fisher Scientific TNN Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:500

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human TNN. Recombinant protein control fragment (Product #RP-94145). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:TNN,uniProtId:Q9UQP3-1,ncbiNodeId:9606,antigenRange:36-128,antigenLength:1299,antigenImageFileName:PA5-55411_TNN_Q9UQP3-1_Rabbit.svg,antigenImageFileNamePDP:PA5-55411_TNN_Q9UQP3-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.3 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2648789

Product Specific Information

Immunogen sequence: KEQQVTVSHT YKIDVPKSAL VQVDADPQPL SDDGASLLAL GEAREEQNII FRHNIRLQTP QKDCELAGSV QDLLARVKKL EEEMVEMKEQ CSA

Highest antigen sequence identity to the following orthologs: Mouse - 84%, Rat - 85%.

Target Information

Extracellular matrix protein that seems to be a ligand for ITGA8:ITGB1, ITGAV:ITGB1 and ITGA4:ITGB1 (PubMed:17909022). Involved in neurite outgrowth and cell migration in hippocampal explants. During endochondral bone formation, inhibits proliferation and differentiation of proteoblasts mediated by canonical WNT signaling. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (PubMed:19884327). Expressed in most mammary tumors, may facilitate tumorigenesis by supporting the migratory behavior of breast cancer cells (PubMed:17909022). [UniProt]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.