Thermo Fisher Scientific NAG-1 Polyclonal Antibody, HRP

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Store vial at 4°C prior to restoration.
• For extended storage, aliquot contents and freeze at -20°C or below.
• Avoid cycles of freezing and thawing.
• Centrifuge product if not completely clear after standing at room temperature.
• Stable for several weeks at 4°C as an undiluted liquid.
• Dilute only prior to immediate use.

This antibody specifically reacts with a variant sequence of human NAG-1 protein from human tissues.
BLAST analysis suggests partial reactivity with NAG-1 from chimpanzee and macaque (92% homology).
Cross-reactivity with NAG-1 from other sources has not been determined.

Target Information

GDF-15 belongs to the TGF-beta cytokine family, which plays an important role in prenatal development, postnatal growth, and tissue remodeling.
It is predominantly expressed in the placenta and to a lesser extent in other tissues.
Presence in amniotic fluid and elevated levels in sera of pregnant women suggest involvement in gestation and embryonic development.
GDF-15 generally exhibits tumor-suppressive activity and is a major factor induced by p53 pathway activation.
Serum levels correlate positively with neoplastic progression in several cancers, including colorectal, pancreatic, and prostate cancers.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.