Thermo Fisher Scientific Human DISC1 Synthetic Peptide

Applications

Control (Ctrl)

• Assay-dependent

Blocking Assay (BLOCK)

• Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 18 amino acids near the center of human DISC1.
PEP-0540 can be used as a blocking peptide with polyclonal antibody PA5-20423.

Target Information

DISC1 (Disrupted in Schizophrenia 1) is a multifunctional protein that interacts with multiple proteins of the centrosome and cytoskeletal system, and is involved in neuronal functions dependent on proper cytoskeletal regulation, including neuronal migration, neurite architecture, and intracellular transport.

Regions of the brain expressing DISC1 include the hippocampus, lateral septum, amygdala, cerebral cortex, cerebellum, and paraventricular hypothalamus. Loss of DISC1 function results in differences in structural organization. The DISC1 gene locus is associated with schizophrenia due to chromosomal translocations.

DISC-1 encodes a large protein predicted to contain a globular N-terminal domain and a helical C-terminal domain, both capable of forming interactions with other proteins. DISC-1 interacts with proteins involved in the centrosome and cytoskeletal system (MIPT3, MAP1A, NUDEL), receptor localization (alpha-actinin 2, beta 4-spectrin), and signal transduction (ATF-4, ATF-5).

Therefore, DISC-1 is thought to be involved in intracellular transport, neurite architecture, and neuronal migration, processes potentially pathogenic in schizophrenia. Decreased expression of DISC1 in neurons accelerates neuronal integration, causing aberrant morphological development, suggesting a role in dendritic development and synapse formation.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.