Thermo Fisher Scientific Human TEM7 Synthetic Peptide

Applications

Control (Ctrl)

• Assay-dependent

Blocking Assay (BLOCK)

• Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 16 amino acids near the carboxy terminus of human TEM7.
PEP-0544 can be used as a blocking peptide with polyclonal antibody PA5-20427.

Target Information

Using SAGE (Serial Analysis of Gene Expression) technology, St. Croix et al. identified 46 genes whose expression is specifically elevated in tumor-associated endothelium.
Nine of these genes were prominently expressed only in tumor endothelial cells (EC) and named as Tumor Endothelial Markers (TEMs, TEM1–9).

TEM7 (Tumor Endothelial Marker 7) transcripts are specifically expressed in the endothelium of colorectal cancer and primary cancers of lung, pancreas, breast, and brain.
TEM7 expression is observed in both primary and metastatic tumor endothelium.
Other members of this family (TEM1, 3, 4, 5, 8, and 9) show similar expression patterns in lung and brain tumors and liver metastasis.

Since many genes differentially expressed in tumor endothelium are also expressed during angiogenesis, these newly discovered genes may provide important resources for basic and clinical studies of human angiogenesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.