Thermo Fisher Scientific Human DISC1 Synthetic Peptide

Applications

Control (Ctrl)

• Assay-dependent

Blocking Assay (BLOCK)

• Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 13 amino acids near the amino terminus of human DISC1.
PEP-0539 can be used as a blocking peptide with polyclonal antibody PA5-20422.

Target Information

DISC1 (Disrupted in Schizophrenia 1) is a multifunctional protein that interacts with multiple proteins of the centrosome and cytoskeletal system. It is involved in neuronal functions dependent on proper cytoskeletal regulation, including neuronal migration, neurite architecture, and intracellular transport.

Regions of the brain expressing DISC1 include the hippocampus, lateral septum, amygdala, cerebral cortex, cerebellum, and paraventricular hypothalamus. Loss of DISC1 function results in differences in structural organization.

The DISC1 gene locus is associated with schizophrenia due to chromosomal translocations. DISC1 encodes a large protein predicted to contain a globular N-terminal domain and a helical C-terminal domain, capable of forming interactions with other proteins.

DISC1 interacts with proteins involved in the centrosome and cytoskeletal system (MIPT3, MAP1A, NUDEL), membrane receptor localization (α-actinin 2, β4-spectrin), and signal transduction (ATF-4, ATF-5). Therefore, DISC1 is thought to participate in intracellular transport, neurite architecture, and neuronal migration, processes implicated in schizophrenia pathogenesis.

Decreased expression of DISC1 in neurons causes accelerated neuronal integration and aberrant morphological development, suggesting a role in dendritic development and synapse formation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.