Thermo Fisher Scientific H2AX Polyclonal Antibody
Rabbit polyclonal antibody targeting the C-terminus of human histone H2AX. Suitable for WB and IHC applications. Detects phosphorylated H2AX (γ-H2AX) related to DNA damage response. Supplied as a liquid at 1 mg/mL, stored at 4°C, shipped on wet ice.
✨AI 추천 연관 상품
AI가 분석한 이 상품과 연관된 추천 상품들을 확인해보세요
연관 상품을 찾고 있습니다...
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:2,000 |
Note: For IHC, epitope retrieval with citrate buffer (pH 6.0) is recommended for FFPE tissue sections.
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | C-terminus of human histone H2AX |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Shelf Life: Recommended shelf life is 1 year from date of receipt.
Target Information
Histone H2A.X (H2AX) is a member of the histone H2A family, one of the four core histones forming the nucleosome core particle. In eukaryotes, DNA double strand breaks (DSBs) trigger phosphorylation of serine 139 at the C-terminus of H2AX, generating γ-H2AX. This phosphorylation can be detected by Western blotting or immunofluorescence to assess DSB frequency.
Phosphorylation of H2AX is mediated by phosphatidylinositol 3-kinases, including ATM, DNA-PK, and ATR. H2A.X consists of 143 amino acids and is synthesized in both G1 and S phases. Its mRNA exists in two forms: a short replication-type (575 bases) and a long basal-type (1600 bases). The gene maps to human chromosome 11q23.2–q23.3.
Histone H2A.X contributes to nucleosome structure and DNA repair by regulating MDC1 (mediator of DNA damage checkpoint protein 1) recruitment to DNA damage sites.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
🏷️Thermo Fisher Scientific 상품 둘러보기
동일 브랜드의 다른 상품들을 확인해보세요
Thermo Fisher Scientific
Thermo Fisher Scientific Alexa Fluor 647 Microscale Protein Labeling Kit
1,035,200원
Thermo Fisher Scientific
Thermo Fisher Scientific MLL1 Polyclonal Antibody
730,200원
Thermo Fisher Scientific
Thermo Fisher Scientific H2AX Polyclonal Antibody
194,600원
Thermo Fisher Scientific
Thermo Fisher Scientific H2AX Polyclonal Antibody
658,900원
Thermo Fisher Scientific
Thermo Fisher Scientific H2AX Polyclonal Antibody
658,900원
배송/결제/교환/반품 안내
배송 정보
| 기본 배송비 |
| 교환/반품 배송비 |
|
|---|---|---|---|
| 착불 배송비 |
| ||
| 교환/반품 배송비 |
| ||
결제 및 환불 안내
| 결제수단 |
|
|---|---|
| 취소 |
|
| 반품 |
|
| 환급 |
|
교환 및 반품 접수
| 교환 및 반품 접수 기한 |
|
|---|---|
| 교환 및 반품 접수가 가능한 경우 |
|
| 교환 및 반품 접수가 불가능한 경우 |
|
교환 및 반품 신청
| 교환 절차 |
|
|---|---|
| 반품 절차 |
|