Thermo Fisher Scientific MLL1 Polyclonal Antibody
MLL1 단백질을 인식하는 Rabbit Polyclonal 항체로, WB 및 IP에 사용 가능. Human에 반응하며 Mouse에도 예측 반응. 항원 친화 크로마토그래피로 정제된 액상 항체로, 4°C에서 보관. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–10 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residues 720–780 of human myeloid/lymphoid or mixed-lineage leukemia 1 (KMT2A) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Phosphate/Tris citrate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, predicted to react with Mouse
Target Information
KMT2A (also known as MLL1) is a histone methyltransferase essential for early development and hematopoiesis. It functions as a catalytic subunit of the MLL1/MLL complex, mediating methylation of Lys-4 of histone H3 (H3K4me) and acetylation of Lys-16 of histone H4 (H4K16ac).
KMT2A specifically mediates H3K4me, a mark for epigenetic transcriptional activation. It has weak methyltransferase activity alone and requires other MLL1 complex components for full activity. KMT2A shows reduced activity toward phosphorylated or dimethylated histone H3 and higher activity toward acetylated H3. It is required for transcriptional activation of HOXA9 and promotes PPP1R15A-induced apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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