Thermo Fisher Scientific DRAK2 Polyclonal Antibody
Rabbit polyclonal antibody recognizing human DRAK2 (STK17B). Validated for WB and ICC/IF. Detects ~45 kDa band in Jurkat lysate. Supplied as liquid, 1 mg/mL in PBS with 0.02% sodium azide. For research use only.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.5 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A peptide corresponding to amino acids 351–365 of human DRAK2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Ion-exchange chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | 2–8°C for up to 3 months; long-term storage at -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11155249 |
Product Specific Information
- In Western blot applications, this antibody detects a band at approximately 45 kDa.
- Suggested positive control: Jurkat cell lysate.
- PA5-19927 can be used with blocking peptide PEP-0052.
Target Information
STK17B (DRAK2) is a member of the serine/threonine kinase family related to death-associated protein kinase, which triggers apoptosis.
It plays a critical role in T-cell survival and is a potential therapeutic target for autoimmune diseases.
Deficiency or inhibition of STK17B can influence autoimmune disease susceptibility without general immune suppression.
Protein kinases are key players in signal transduction responding to various stimuli. Overexpression of related kinases such as ZIP kinase induces apoptotic morphology in NIH 3T3 cells.
Sanjo et al. identified DRAK1 and DRAK2 (Death Receptor Associated Kinases 1 and 2), which share significant homology with ZIP kinase and DAP kinase.
The C-terminal domain of DRAKs is important for induction of apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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