Thermo Fisher Scientific Phospho-c-Met (Tyr1230, Tyr1234, Tyr1235) Polyclonal Antibody
Phospho-c-Met (Tyr1230, Tyr1234, Tyr1235) 폴리클로날 항체로 인간 및 마우스 반응성을 보입니다. Western blot, IHC, ICC 등 다양한 응용에 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. 암 연구 및 MET 신호전달 분석에 적합합니다.
- 카탈로그번호
- 44888G
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 19 publications |
| Immunohistochemistry (IHC) | - | View 8 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | - | View 2 publications |
| Immunocytochemistry (ICC/IF) | - | View 2 publications |
| Immunoprecipitation (IP) | - | View 1 publication |
| peptide-ELISA (pep-ELISA) | Assay-dependent | - |
| Miscellaneous PubMed (Misc) | - | View 6 publications |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Dog, Hamster, Human, Mouse, Virus |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Chemically synthesized phosphopeptide derived from human c-Met region containing tyrosines 1230, 1234, and 1235. Sequence conserved in mouse and rat. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Dulbecco’s PBS, pH 7.3, with 1 mg/mL BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533787 |
Target Information
MET (cMET) is a receptor-like tyrosine kinase whose dysregulation is associated with various human malignancies. Upon ligand activation, MET interacts with PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, and STAT3, leading to activation of signaling cascades such as RAS-ERK, PI3K-AKT, and PLCγ-PKC.
MET is involved in embryonic development processes including gastrulation, muscle and neuron formation, angiogenesis, and kidney development. In adults, MET contributes to wound healing, organ regeneration, and tissue remodeling.
Dysregulation of MET has been linked to gastric, renal, and breast cancers, making it a significant target for cancer therapeutics and diagnostic research.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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