Thermo Fisher Scientific 14-3-3 zeta Polyclonal Antibody
14-3-3 zeta 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot 및 ELISA에 적합. Human, Mouse, Rat 시료 반응성. Affinity 정제 및 고농도(2.08 mg/mL) 액상 형태. 세포 내 신호전달 및 단백질 상호작용 연구에 유용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
ELISA
- Tested Concentration: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 1–100 of human YWHAZ (NP_001129171.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.08 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2913870 |
Product Specific Information
- Target localization: Cytoplasm, Melanosome
- Immunogen sequence:
MDKNELVQKA KLAEQAERYD DMAACMKSVT EQGAELSNEE RNLLSVAYKN VVGARRSSWR VVSSIEQKTE GAEKKQQMAR EYREKIETEL RDICNDVLSL
Target Information
The 14-3-3 family consists of at least seven isoforms of highly conserved homo- and heterodimeric proteins expressed in all eukaryotic cells. These proteins regulate signal transduction by binding to serine-phosphorylated proteins.
Through interactions with Cdc25C, 14-3-3 regulates cell cycle entry, and by binding Bad, it prevents apoptosis. Other known binding partners include protein kinase C family members, Cbl, IRS-1, polyoma middle-T antigen, nitrate reductase, S-raf, and the IGF-1 receptor.
Detection of 14-3-3 proteins in cerebrospinal fluid aids in the differential diagnosis of Creutzfeldt-Jakob disease and other prion diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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