Thermo Fisher Scientific MAP2K4 Polyclonal Antibody
MAP2K4 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, ELISA에 적합합니다. 인간, 마우스, 랫트 반응성을 가지며, 고순도 Affinity Chromatography로 정제되었습니다. 세포 스트레스 및 암 관련 연구에 활용 가능합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 300–399 of human MAP2K4 (NP_003001.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.92 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2913868 |
Product Specific Information
- Positive test controls: SH-SY5Y, BT-474, MCF-7, mouse thymus, mouse liver, rat liver
- Subcellular localization: Cytoplasm, Nucleus
Immunogen sequence:
LATGRFPYPK WNSVFDQLTQ VVKGDPPQLS NSEEREFSPS FINFVNLCLT KDESKRPKYK ELLKHPFILM YEERAVEVAC YVCKILDQMP ATPSSPMYVD
Target Information
MAP2K4 (MEK4) serine/threonine kinase (mitogen-activated protein kinase 4) is a dual specificity kinase of the STE7 family that phosphorylates and activates JNK1 and -2 as well as p38. MAP2K4 preferentially phosphorylates the tyrosine residue of JNKs. It mediates various physiological and pathophysiological processes such as responses to cellular stresses and inflammatory cytokines. MAP2K4 plays an important role in carcinogenesis; loss-of-function mutations have been found in lung and pancreatic tumors, while a pro-oncogenic role has also been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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