Thermo Fisher Scientific INSM1 Monoclonal Antibody (CL11630)
INSM1 단백질을 인식하는 Mouse IgG1 단일클론 항체로, 인간 시료에 반응합니다. IHC(P) 실험에 적합하며 1:50~1:200 희석 범위에서 사용 가능합니다. Protein A로 정제된 액상 항체로 장기 보관 시 -20°C에서 안정적으로 유지됩니다.
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Applications
Tested Dilution
- Immunohistochemistry (Paraffin) (IHC (P)): 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CL11630 |
| Immunogen | Recombinant protein corresponding to Human INSM1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2926318 |
Product Specific Information
The antibody solution should be gently mixed before use. Optimal concentrations and conditions for each application should be determined by the user.
Target Information
IA-1, also known as INSM1, is an essential five zinc-finger transcription factor initially identified from an insulinoma cDNA library and expressed in the developing nervous system. In mice, IA-1 is expressed as early as E9.5 in the forebrain, midbrain, hindbrain, spinal cord, retina, and olfactory bulb. It functions as a transcriptional repressor and participates in signaling pathways including Notch, sonic hedgehog, and Ngn3 during pancreatic endocrine cell differentiation. IA-1 is also expressed in multiple tumors, including most neuroendocrine tumors and nearly all small cell lung carcinomas, suggesting its potential as a therapeutic target in cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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