Thermo Fisher Scientific CD40 Recombinant Rabbit Monoclonal Antibody (BLR056F)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Epitope retrieval with citrate buffer (pH 6.0) is recommended for FFPE cell sections.

Target Information

The CD40 antigen is a single chain glycoprotein that belongs to the tumor necrosis factor/nerve growth factor superfamily and shares significant homology with the Hodgkin’s disease-associated antigen CD30. CD40 is expressed on all B cells except plasma cells, as well as on some epithelial cells, carcinomas, and lymphoid dendritic cells.

CD40 plays a critical role in immune and inflammatory responses, including:

• T cell-dependent immunoglobulin class switching
• Memory B cell development
• Germinal center formation

AKNA transcription factor regulates CD40 expression, influencing homotypic cell interactions. Adaptor protein TNFR2 interacts with CD40 to mediate signal transduction. The CD40–ligand interaction is implicated in amyloid-beta-induced microglial activation, potentially an early event in Alzheimer’s disease pathogenesis.

Two alternatively spliced transcript variants of CD40 encoding distinct isoforms have been reported.
Diseases associated with CD40 dysfunction include:

• Type 3 Hyper-IgM immunodeficiency
• CD40 ligand deficiency

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.