Thermo Fisher Scientific Periostin Polyclonal Antibody
인간 Periostin 단백질을 인식하는 염소 유래 폴리클로날 항체로, Western blot에 최적화되어 있습니다. 모든 보고된 isoform을 인식하며, 고감도의 Peptide ELISA 검증 완료. 연구용으로만 사용 가능하며 -20°C 보관 권장.
- 카탈로그번호
- PA5142982
- 판매단위
- pk
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Thermo Fisher Scientific Periostin Polyclonal Antibody
Applications
- Western Blot (WB)
Tested Dilution: 0.1–0.3 µg/mL
Publications: [References not provided]
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence C-TTQRYSDASKLREE |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2933622 |
Product Specific Information
- This antibody is expected to recognize all reported isoforms (NP_006466.2; NP_001129406.1; NP_001129407.1; NP_001129408.1).
- Tested in Peptide ELISA: antibody detection limit dilution 1:128,000.
Target Information
Periostin (PN), also known as osteoblast-specific factor 2 (OSF-2), is a disulfide-linked protein originally isolated as an osteoblast-specific factor. It is a secreted protein that binds heparin and functions as a ligand for αVβ3 and αVβ5 integrins.
In preosteoblasts, Periostin acts as a cell adhesion molecule and plays a role in osteoblast recruitment, spreading, and attachment.
Periostin is mainly detected in lower gastrointestinal tract, aorta, stomach, placenta, uterus, and breast tissues but is up-regulated in epithelial ovarian tumors and overexpressed in breast cancer.
Expression of Periostin is increased by bone morphogenetic protein (BMP2) and transforming growth factor beta 1 (TGF-β1).
Periostin contains a typical signal sequence, followed by a cysteine-rich domain, a fourfold repeated domain homologous to the insect protein fasciclin, and a C-terminal domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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