Thermo Fisher Scientific Periostin Polyclonal Antibody

Thermo Fisher Scientific Periostin Polyclonal Antibody

Applications

• Western Blot (WB)

Tested Dilution: 0.1–0.3 µg/mL
Publications: [References not provided]

Product Specifications

Product Specific Information

• This antibody is expected to recognize all reported isoforms (NP_006466.2; NP_001129406.1; NP_001129407.1; NP_001129408.1).
• Tested in Peptide ELISA: antibody detection limit dilution 1:128,000.

Target Information

Periostin (PN), also known as osteoblast-specific factor 2 (OSF-2), is a disulfide-linked protein originally isolated as an osteoblast-specific factor. It is a secreted protein that binds heparin and functions as a ligand for αVβ3 and αVβ5 integrins.
In preosteoblasts, Periostin acts as a cell adhesion molecule and plays a role in osteoblast recruitment, spreading, and attachment.
Periostin is mainly detected in lower gastrointestinal tract, aorta, stomach, placenta, uterus, and breast tissues but is up-regulated in epithelial ovarian tumors and overexpressed in breast cancer.
Expression of Periostin is increased by bone morphogenetic protein (BMP2) and transforming growth factor beta 1 (TGF-β1).
Periostin contains a typical signal sequence, followed by a cysteine-rich domain, a fourfold repeated domain homologous to the insect protein fasciclin, and a C-terminal domain.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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