Thermo Fisher Scientific MKP-1 Polyclonal Antibody
MKP-1 단백질을 인식하는 Thermo Fisher의 Rabbit Polyclonal 항체로, Human 시료에 반응합니다. Western blot과 Immunocytochemistry에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. PBS/glycerol 용액 형태로 제공되며, 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 0.04–0.4 µg/mL
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human DUSP1. Recombinant protein control fragment (Product #RP-105479). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2791967 |
Product Specific Information
Immunogen sequence:
QVLAPHCSAE AGSPAMAVLD RGTSTTTVFN FPVSIPVHST NSALSYLQS
Target Information
The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative or heat stress and growth factors. It encodes a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family and shows significant amino acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus.
The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by dephosphorylating both phosphothreonine and phosphotyrosine residues. It also suppresses MAP kinase activation by oncogenic ras in Xenopus oocyte extracts.
Thus, DUSP1 may play an important role in the human cellular response to environmental stress and in the negative regulation of cellular proliferation.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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